Pesquisa clínica para desenvolvimento de um fluxograma de abordagem terapêutica para tumores gastroesofágicos e colorretais, que inclua biomarcadores preditores de resposta que auxiliem na determinação da conduta e desenvolvimento…

Pesquisa clínica para desenvolvimento de um fluxograma de abordagem terapêutica para tumores gastroesofágicos e colorretais, que inclua biomarcadores preditores de resposta que auxiliem na determinação da conduta e desenvolvimento da terapia personalizada, com o intuito de otimizar os desfechos clínicos e a qualidade de vida dos pacientes atendidos pelo SUS, promovendo a gestão eficiente dos recursos, auxiliando a decisão médica, e permitindo a seleção da terapia mais adequada a cada paciente. 100% de coleta e processamento de amostras Aquisição de Material Laboratorial - Escalpe BD Vacutainer® Safety-LokTM - 21G- Tubo p/coleta de sangue a vacuo com anticoagulante EDTA 3ML (LILAS) BD Vacutainer código: 360056 - bandeja com 100 tubos- TF-1000-R-S-C Ponteira PP 1000uL c/filtro caixa com 960 (cx c/ 10 racks, com 96 ponteiras, Axygen- MCT-200-C Microtubo cônico, 2 ml, pacote com 500 unidades- 72.703.416 Microtubo de 1,5 ml com base e tampa graduado, espaço para escrita, pacote com 100 unidades marca Sarstedt- 72694106 Microtubo 2,0mL, estéril, tampa de rosca, anel de vedação pacote c/100 marca Sarstedt- 65713009 Inserto para tampa de tubos cor branca, pacote com 500 marca Sarstedt- 65713006 Inserto para microtubos com tampa de rosca alceada, cor azul, pacote com 500 unidades- 430291 Tubo de 50ml pct com 500 - Corning Prestação de serviços durante 36 meses Pagamentos Bolsistas 4 bolsistas x R$ 4.320,00 x 32 meses Pagamentos de profissionais de RH - Enfermeiro de Pesquisa 2 Enfermeiros de Pesquisa x R$ 8.190,5631 x 32 meses Pagamentos de profissionais de RH - Monitor de Pesquisa Pagamento de Bolsistas 2 bolsistas x R$ 6.326,25 x 32 meses 100% do material adquirido TF-200-R-S-C Ponteiras, 1-200ul, c/filtro, cx c/ 10 racks, com 96 ponteiras cada, AxygenOptiview Dab Detection Kit Cod. 6396500001Rabbit Monoclonal Negative Control Ig Cod. 6683380001TOMO - 11/90 Microscope Slides cod. 8082286001LCS (Predilute) Cod. 5264839001Reaction Buffer Concentrate (10X) cod.5353955001EZ Prep Concentrate (10x) Cod. 5279771001BLUING REAGENT cod. 5266769001Cell Conditioner 1 (CC1) cod. 5279801001VENTANA PD-L1 (SP142) Assay-US Export - Cod. 8008540001VENTANA PD-L1 (SP263) Assay IVD W - Cod. 9484515001VENTANA CLDN18 (43-14A) RxDx Assay W Cod. 962065600172.380.004 Criotubo CryoPure, 2 ml, tubo amarela, Rosca interna, com anel de vedação em silicone, volume nominal: 2 ml, Cryo Performance Tested, 50 unid./pacote marca Sarstedt72.380.007 Criotubo CryoPure, 2 ml, tubo: PP, tampa de rosca QuickSeal, tampa montada, PP, violeta, Rosca interna, com anel de vedação em silicone, volume nominal: 2 ml, Cryo Performance Tested, 50 unid./pacote Sarstedt 72730106 Microtubo de 0,5 ml com base e tampa graduado, espaço para escrita, pacote com 100 unidades65713004 Inserto para microtubos com tampa de rosca alceada, cor amarela, pacote com 500 unidades65713005 Inserto para microtubos com tampa de rosca alceada, cor verde, pacote com 500 unidades4TI-0689 TUBEMARKER RIBBON, BLACK, 300 M X 40 MM; 1 ROLLcód. 112711 - LAMINA 26x76mm ESPESSURA 1,0-1,2mm VIDRO ALCALINO BRANCO STARFROST SILANIZADA EXTREMIDADE BRANCA LAPIDADA 45º C/50undscód. 102432 - LAMINULA RETANGULAR 24X32mm, VIDRO BOROSILICATO, ESPESSURA DE 0,13- 0,17mm C/100undsRNase Away (10328011)MicroAmp™ Fast Optical 96-Well Reaction Plate, 0.1 mL (4346907)MicroAmp™ Optical Adhesive Film - 100 covers (4311971)kit QIAseq miRNA Library Kit (96 ensaios, 331505)kit QIAseq miRNA 96 Index IL UDI-A (96 ensaios - 331905) para idexar as bibliotecaskit para quantificação das bibliotecas, QIAseq Library Quant Assay Kit 333314 QUBIT 1X DSDNA HS 500 ASSAYS (Q33231)QUBIT RNA HS ASSAY - 500 testes (Q32855)QUANTIT KIT DE ENSAIO RNA AM ESPECTRO - 500 ENSAIOS (Q10211)AM9849 Tampão TE_ PH 8.0 500 mLÁgua ultrapura livre de DNAse/RNAse 500 ML COD. 1097701570011-044 Frasco contendo PBS (10X), pH 7.4, 500mL Aquisição de Servidor Aquisição de Equipamentos 5811000622 - Centrifuga Eppendorf IVD 5810 R, Refrigerada, Com Rotor S-4-104Com Adaptadores MDF-U731M-PA - Freezer vertical, -30ºC,690 L - PanasonicMPR-S300H-PA - Refrigerador compacto com cap. para 340 Litros - PanasonicQ33327 - PACOTE INICIAL INSTRUMENTO QUBIT FLEX WIFI E CABOND-ONE-W - EQUIPAMENTO NANODROP ONE ESPECONE ESPECTOFOTOMETRO - High Sensitivity RNA ScreenTape (5067-5579)- RNA ScreenTape (5067-5576)- High Sens. RNA ScreenTape Sample Buffer (5067-5580)- RNA ScreenTape Sample Buffer (5067-5577)- Kit Rhapsody WTA Reagente – 4 Pacotes COD. 665915- KIT REAG AMOS MULTIP AB-O SNLGCELL RUO COD. 633781- 4583 - Tissue tek Sakura (O.C.T. Compound)- 20104706 - NovaSeq™ X Series 25B Rgt Kit 300 Cyc - Illumina- 20028312 - NVSEQ 6000 S4 Rgt Kit v1.5 (300cyc)- Illumina Stranded Total RNA Prep, Ligation with Ribo-Zero Plus (96 Samples) 20040529- 20028313 NVSEQ 6000 S4 Rgt Kit v1.5 (200cyc)- (200Am)- 20025520 - ILMN DNA LP (S)Tag (96 Spl) - Illumina DNA Prep, (S) Tagmentation reagents sufficient for 96 samples. Aquisição de Computador e Notebook 20090138 - Insights - Oncology Samples - Illumina Connected Insights prepaid oncology samples on per genome equivalent basis starting from VCF: one genome is equivalent to 2 exomes, 3 large and 6 small panel samples. Any unused samples will automatically roll over provided that the annual subscription to Illumina Connected Insights (20090137) is renewed on an annual basis. Access to a set of oncology knowledge bases is included.20028319 - NVSEQ 6000 S1 Rgt Kit v1.5 (100cyc)20090138 - Insights - Oncology Samples - Illumina Connected Insights prepaid oncology samples on per genome equivalent basis starting from VCF: one genome is equivalent to 2 exomes, 3 large and 6 small panel samples. Any unused samples will automatically roll over provided that the annual subscription to Illumina Connected Insights (20090137) is renewed on an annual basis. Access to a set of oncology knowledge bases is included.20041795 - ILMN DNA PCR-Free LPK (96 SPL) - Illumina 20073772 - EMG-FASTQ - Emedgene analysis starting from FASTQ on a per sample genome equivalent basis, whereby 1 genome is equivalent to 2 exomes or 6 panels. Any unused samples will automatically roll over provided that the Support and Maintenance fee is renewed on an annual basis.20076914 - Twist ILMN EXM 2.5 Pnl, 8 rxn - Twist Bioscience® for Illumina Exome 2.5 Panel (8 Reactions) Kit20025523 - ILMN DNA LP w/Enrich (S)Tag (16 Spl)20073772 - EMG-FASTQ - Emedgene analysis starting from FASTQ on a per sample genome equivalent basis, whereby 1 genome is equivalent to 2 exomes or 6 panels. Any unused samples will automatically roll over provided that the Support and Maintenance fee is renewed on an annual basis.20093180 - Twist for ILMN Mitochondrial Panel Spl20042038 - ILMN Analytics 1 iCredit - iCredits are used for data storage and analysis on either BaseSpace Sequence Hub or Illumina Connected Analytics 20042109 -BSSH Professional Annual Subscription - Annual subscription for BaseSpace Sequence Hub Professional. The Professional tier Includes 500 iCredits to get started quickly with BaseSpace apps and data storage, 1 workgroup to enhance collaboration, and access to powerful APIs.20060057 - Illumina Purification Bead, 100mL - Illumina Purification Bead, 100mLILMN Analytics 1 iCredit - iCredits are used for data storage and analysis on either BaseSpace Sequence Hub or Illumina Connected Analytics. - 20042038kit Illumina® RNA UD Indexes Set A, Ligation (96 Indexes, 96 Samples) -20091655kit Illumina® RNA UD Indexes Set B, Ligation (96 Indexes, 96 Samples) -2009165720091654 - ILMN DNA/RNA UDI A Tag 96 Idx 96 Spl - Illumina® DNA/RNA UD Indexes Set A20091654 - ILMN DNA/RNA UDI A Tag 96 Idx 96 Spl20042038 - ILMN Analytics 1 iCredit - iCredits are used for data storage and analysis on either BaseSpace Sequence Hub or Illumina Connected Analytics. Pagamento de profissionais de RH 1 Pesquisador Júnior x R$ 10.139,8309 x 32 meses 20028319 - MiSeq® Reagent Nano Kit v2 (300 Cycles)15036522 - MiSeq® Reagent Nano Kit v2 (300 Cycles)15036522 - MiSeq® Reagent Nano Kit v2 (300 Cycles)20091656 - ILMN DNA/RNA UDI B Tag 96 Idx 96 Spl20091658 - ILMN DNA/RNA UDI C Tag 96 Idx 96 Spl15017872 - PhiX CONTROL V3 KIT15014442- INFINIUM FFPE QC KIT - IlluminaILMN Analytics 1 iCredit - iCredits are used for data storage and analysis on either BaseSpace Sequence Hub or Illumina Connected Analytics. - 20042038MX-OE-S-8-L - Logger iMini Temperatura ExternaA9647-100G Albumina sérica bovina (BSA)1116092504 - HISTOSEC PASTILHAS 56-58ºC, 4 X 2,5KGkit QIAseq miRNA Library Kit (96 ensaios, 331505)kit QIAseq miRNA 96 Index IL UDI-A (96 ensaios - 331905) para idexar as bibliotecasAllPrep DNA/RNA/miRNA Universal Kit (80224)kit para quantificação das bibliotecas, QIAseq Library Quant Assay Kit 333314QIAamp DNA Blood Midi Kit (100) (51185) - QiagenTF-100-R-S Ponteira PP 100uL c/filtro 100% de amostras avaliadas - Loading Tips, 1 Pk. For use with Agilent 4150 and 4200 TapeStation systems. (5067-5598) 1 caixa contém 112 ponteiras.- Genomic DNA ScreenTape, part of the TapeStation system - 5067-5365- Genomic DNA Reagents containing Sample Buffer and Ladder, part of the TapeStation systems. - 5067-5366- High Sensitivity D1000 ScreenTape , part of the TapeStation system - 5067-5584- High Sensitivity D1000 Reagents, containing Sample Buffer and Ladder, part of the TapeStation systems. - 5067-5585- Qubit Flex tubes - 125 strips c/8 tubos(Q33252)- CONJ ENSAIO 1X - DSDNABR 500REACOES (Q33266) 7000017 Sample Kit for PhenoCyclerFusion7000002 Assay Reagent for PhenoCycler7000019 10X Buffer Kit for PhenoCycler-Fusion4550071 Anti-Hu FOXP3(AKYP0102)-BX031 - Alexa FluorTM 647 for PhenoCycler4550068 Anti-Hu TCF1(AKYP0099)-BX061 - Alexa FluorTM 647 for PhenoCycler4550038 Anti-Hu PD1(AKYP0070)-BX046 - Alexa FluorTM 647 for PhenoCycler4550128 Anti-Hu PDL1(AKYP0103)-BX067 - Alexa FluorTM 647 for PhenoCycler4250062 Anti-Hu IFNG(AKYP0093)-BX020 - Atto 550 for PhenoCycler4550112 Anti-Hu CD4(AKYP0048)-BX003 - Alexa FluorTM 647 for PhenoCycler 4250104 Anti-Hu CD31(AKYP0047)- BX001 - Atto 550 for PhenoCycler 4250091 Anti-HubCatenin1(AKYP0068)-BX096 - Atto 550 for PhenoCycler 4450092 Anti-HuBeta actin(AKYP0072)-BX117 - Alexa FluorTM 750 for PhenoCycler 4250094 Anti-HuPodoplanin(AKYP0007)-BX1 21 - Atto 550 for PhenoCycler 4450084 Anti-HuCaveolin(AKYP0115)-BX086 - Alexa FluorTM 750 for PhenoCycler 4250067 Anti-HuTOX(AKYP0098)- BX060 - Atto 550 for PhenoCycler 4450095 Anti-HuHLADR(AKYP0063)-BX033 -Alexa FluorTM 750 for PhenoCycler 4450094 Anti-HuCD20(AKYP0049)- BX064 - Alexa FluorTM 750 for PhenoCycler7000003 Nuclear Stain for PhenoCycler 7000006 96-wellplates for PhenoCycler7000007 96-well plate seals for PhenoCycler 4550125 Anti-Hu CD3e(AKYP0062)-BX080 - Alexa FluorTM 647 for PhenoCycler 4450041 Anti-HuCD44(AKYP0073)-BX005 - Atto 550 for PhenoCycler 4250099 Anti-HuCD45(AKYP0074)-BX021 - Atto 550 for PhenoCycler 4450047 Anti-HuCD14(AKYP0079)-BX037 - Atto 550 for PhenoCycler 4450096 Anti-Hu/MuKi67(AKYP0052)-BX047 - Alexa FluorTM 750 for PhenoCycler 4550127 Anti-HuCD45RO(AKYP0059)-BX017 - Alexa FluorTM 647 for PhenoCycler 4450093 Anti-HuPanCytokeratin(AKYP0053)-BX0 66 - Alexa FluorTM 750 for PhenoCycler 4250021 Anti-HuEcadherin(AKYP0057)-BX014 - Atto 550 for PhenoCycler 4450049 Anti-HuSMA(AKYP0081)- BX013 - Alexa FluorTM 750 for PhenoCycler 4450050 Anti-HuVimentin(AKYP0082)-BX022 - Alexa FluorTM 750 for PhenoCycler 4550122 Anti-HuCollagen IV(AKYP0083)-BX042 - Alexa FluorTM 647 for PhenoCycler 4550133 Anti-Hu CD34(AKYP0088)- BX025 - Alexa FluorTM 647 for PhenoCycler Metabolômica Proteômica ShotGun 20091654 - ILMN DNA/RNA UDI A Tag 96 Idx 96 Spl - Illumina® DNA/RNA UD Indexes Set A20091656 - LMN DNA/RNA UDI B Tag 96 Idx 96 Spl - Illumina® DNA/RNA UD Indexes Set B20091659 - ILMN DNA/RNA UDI C Tag 96 Idx 96 Spl - Illumina® DNA/RNA UD Indexes Set C20028312 - NVSEQ 6000 S4 Rgt Kit v1.5 (300cyc)15036522 - MiSeq® Reagent Nano Kit v2 (300 Cycles)20060059 - ILMN DNA LP (M)Tag (96 Spl, IPB) Três processos de prestações de contas e três auditorias, sendo uma por ano Seis atividades realizadas Elaboração de prestações de contas e auditorias anuais